TOKYO, May 22 (Xinhua) -- Tokyo stocks ended mixed Wednesday as initial buying following a positive overnight lead from Wall Street saw gains erased by ongoing concerns over the future course of the global economy.

The 225-issue Nikkei Stock Average edged up 10.92 points, or 0.05 percent, from Tuesday to close the day at 21,283.37.

The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 4.09 points, or 0.26 percent, to finish at 1,546.21.

Mining and nonferrous metal issues comprised notable gainers, while land transportation, and oil and coal product issues comprised those that declined the most by the close of play.